Associate Editor: K. Allen Beilstein J. Artificial orthogonal bond formations such as the alkyne—azide cycloaddition have enabled selective bioconjugations under mild conditions, yet naturally occurring linkages between native functional groups would be more straightforward to elaborate bioconjugates. Herein, we describe the use of a phosphodiester bond as a versatile option to access various bioconjugates. It should be noted that there is no need to pre-install artificial functional groups and undesired and unpredictable perturbations possibly caused by bioconjugation can be minimized.
Artificial bioconjugates with naturally occurring linkages: the use of phosphodiester
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