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Associate Editor: K. Allen Beilstein J. Artificial orthogonal bond formations such as the alkyne—azide cycloaddition have enabled selective bioconjugations under mild conditions, yet naturally occurring linkages between native functional groups would be more straightforward to elaborate bioconjugates. Herein, we describe the use of a phosphodiester bond as a versatile option to access various bioconjugates. It should be noted that there is no need to pre-install artificial functional groups and undesired and unpredictable perturbations possibly caused by bioconjugation can be minimized.
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Artificial bioconjugates with naturally occurring linkages: the use of phosphodiester

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The 99th percentile of the hsTnI in the overall population was The median of the hsTnI in the overall population was 3. The age and gender had a significant influence on these values. The 99th percentiles of the troponin I measured in the general population in Japan were comparable as the ones derived in the US , Germany, and Singapore. Cardiovascular diseases are the second most common cause of death in Japan, and the number of new cases is continuously growing.
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As of October , the studio had released about original and compilation videos, an average of about six to seven videos per month since the studio's origin in In addition to Matsushima Cross, a number of directors, past and present, have also made videos with Cross. The most prominent among them has been Dragon Nishikawa who had directed over videos or nearly half of all Cross productions by late Among the various prominent AV Idols who have performed in Cross videos, probably the one most closely associated with the company has been Sakura Sakurada who has appeared in 29 Cross videos. Sakurada first starred for Cross in Invincibility Molester released in March and has continued acting for the studio through
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